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Aging & Tissue-Function Studies: Experimental work in animal models has explored relationships between senescent-cell modulation and organ function, frailty markers, and recovery from stressors

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The downstream metabolites of the kynurenine metabolic pathway, quinolinic and kynurenic acids, are neuroactive metabolites acting on the glutamatergic N -metyl-D-aspartate (NMDA) receptor (57)

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